Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

H Paganetti - Physics in Medicine & Biology, 2014 - iopscience.iop.org
Proton therapy treatments are based on a proton RBE (relative biological effectiveness)
relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within …

Ion acceleration by superintense laser-plasma interaction

A Macchi, M Borghesi, M Passoni - Reviews of Modern Physics, 2013 - APS
Ion acceleration driven by superintense laser pulses is attracting an impressive and steadily
increasing effort. Motivations can be found in the applicative potential and in the perspective …

Report of AAPM task group 235 radiochromic film dosimetry: an update to TG‐55

A Niroomand‐Rad, ST Chiu‐Tsao, MP Grams… - Medical …, 2020 - Wiley Online Library
The use of radiochromic film (RCF) dosimetry in radiation therapy is extensive due to its high
level of achievable accuracy for a wide range of dose values and its suitability under a …

A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data

AL McNamara, J Schuemann… - Physics in Medicine & …, 2015 - iopscience.iop.org
Proton therapy treatments are currently planned and delivered using the assumption that the
proton relative biological effectiveness (RBE) relative to photons is 1.1. This assumption …

[HTML][HTML] The European Joint Research Project UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

A Schüller, S Heinrich, C Fouillade, A Subiel… - Physica Medica, 2020 - Elsevier
UHDpulse–Metrology for advanced radiotherapy using particle beams with ultra-high pulse
dose rates is a recently started European Joint Research Project with the aim to develop and …

FLASH: New intersection of physics, chemistry, biology, and cancer medicine

MC Vozenin, BW Loo Jr, S Tantawi, PG Maxim… - Reviews of Modern …, 2024 - APS
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art

P Chaudhary, G Milluzzo, H Ahmed, B Odlozilik… - Frontiers in …, 2021 - frontiersin.org
The use of particle accelerators in radiotherapy has significantly changed the therapeutic
outcomes for many types of solid tumours. In particular, protons are well known for sparing …

[HTML][HTML] Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

D Doria, KF Kakolee, S Kar, SK Litt, F Fiorini, H Ahmed… - AIP Advances, 2012 - pubs.aip.org
The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of
radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser …

LhARA: the laser-hybrid accelerator for radiobiological applications

G Aymar, T Becker, S Boogert, M Borghesi… - Frontiers in …, 2020 - frontiersin.org
The “Laser-hybrid Accelerator for Radiobiological Applications,” LhARA, is conceived as a
novel, flexible facility dedicated to the study of radiobiology. The technologies demonstrated …

Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein

E Bayart, A Flacco, O Delmas, L Pommarel, D Levy… - Scientific reports, 2019 - nature.com
Radiotherapy is a cornerstone of cancer management. The improvement of spatial dose
distribution in the tumor volume by minimizing the dose deposited in the healthy tissues …