Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

Vertebrate pigment patterns are diverse and fascinating adult traits that allow animals to
recognize conspecifics, attract mates, and avoid predators. Pigment patterns in fish are …

Oncogenic alterations to DNA are not transforming in all cellular contexts,. This may be due
to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …

Thyroid hormone (TH) regulates diverse developmental events and can drive disparate
cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment …

Goldfish have been subjected to over 1,000 y of intensive domestication and selective
breeding. In this report, we describe a high-quality goldfish genome (2n= 100), anchoring …

Melanosomes are specialized membrane-bound organelles that synthesize and organize
melanin, ultimately providing color to the skin, hair, and eyes. Disorders in melanogenesis …

The genetic basis of morphological variation provides a major topic in evolutionary
developmental biology. Fish of the genus Danio display colour patterns ranging from …

Color patterns are prominent features of many animals and are of high evolutionary
relevance. In basal vertebrates, color patterns are composed of specialized pigment cells …

Vertebrate pigmentation is a fundamentally important, multifaceted phenotype. Zebrafish,
Danio rerio, has been a valuable model for understanding genetics and development of …