In the human embryo, the genetic program that orchestrates germ cell specification involves
the activation of epigenetic and transcriptional mechanisms that make the germline a unique …

In mammals, sex determination is a process through which the gonad is committed to
differentiate into a testis or an ovary. This process relies on a delicate balance between …

Although genetic mutations have long been known to influence gene expression and
individual phenotype, studies emerging over the past decade indicate that such changes …

In mammals, the timing of meiosis entry is regulated by signals from the gonadal
environment. All-trans retinoic acid (ATRA) signaling is considered the key pathway that …

Primordial germ cells (PGCs) form early in embryo development and are crucial precursors
to functioning gamete cells. Considerable research has focussed on identifying the …

The gene network controlling primordial germ cell (PGC) specification in eutherian
mammals has been exhaustively investigated in mice. The egg-cylinder morphology of the …

In the field of germline development in amniote vertebrates, primordial germ cell (PGC)
specification in birds and reptiles remains controversial. Avians are believed to adopt a …

Introduction Intracranial germ cell tumor (iGCT) is a rare disorder and often occurs during
childhood and adolescence. iGCTs are frequently localized in pineal region and …

During the early development of Placentalia, a distinctive projection emerges at the posterior
embryonic–extraembryonic interface of the conceptus; its fingerlike shape presages …

In the present paper, starting from the observation of heterogeneous expression of the GOF-
18ΔPE-GFP Pou5f1 (Oct3/4) transgene in putative mouse PGC populations settled in the …