Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …

The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

The blood-brain barrier (BBB) is a selective and semipermeable boundary that maintains
homeostasis inside the central nervous system (CNS). The BBB permeability of compounds …

Chronic neuroinflammation has been considered to be involved in the progressive
dopaminergic neurodegeneration in Parkinson's disease (PD). However, the mechanisms …

Cerebrospinal fluid (CSF) flows through the central nervous system (CNS) via the
glymphatic pathway to clear the interstitium of metabolic waste. In preclinical studies …

The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Astrocytes, as the most abundant glial cells in the central nervous system, are tightly
integrated into neural networks and participate in numerous aspects of brain physiology and …