Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

R Sartori, V Romanello, M Sandri - Nature communications, 2021 - nature.com
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function

J Frampton, KG Murphy, G Frost, ES Chambers - Nature metabolism, 2020 - nature.com
A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …

The gut microbiota and healthy aging: a mini-review

S Kim, SM Jazwinski - Gerontology, 2018 - karger.com
The gut microbiota shows a wide inter-individual variation, but its within-individual variation
is relatively stable over time. A functional core microbiome, provided by abundant bacterial …

Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

S Westfall, N Lomis, I Kahouli, SY Dia, SP Singh… - Cellular and molecular …, 2017 - Springer
The gut microbiota is essential to health and has recently become a target for live bacterial
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …

[HTML][HTML] Redox regulation of FoxO transcription factors

LO Klotz, C Sánchez-Ramos, I Prieto-Arroyo… - Redox biology, 2015 - Elsevier
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

Signaling pathways that control muscle mass

A Vainshtein, M Sandri - International journal of molecular sciences, 2020 - mdpi.com
The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

S Du, H Zheng - Cell & bioscience, 2021 - Springer
Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

[HTML][HTML] Forkhead Box O signaling pathway in skeletal muscle atrophy

K Chen, P Gao, Z Li, A Dai, M Yang, S Chen… - The American Journal of …, 2022 - Elsevier
Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis because of disease, aging, and physical inactivity. Patients with skeletal muscle …

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

ME Walsh, A Bhattacharya, K Sataranatarajan… - Aging cell, 2015 - Wiley Online Library
Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major
contributor to disability and frailty in the elderly. Previous studies found a protective effect of …