The increased use of fluoroquinolones has led to increasing resistance to these
antimicrobials, with rates of resistance that vary by both organism and geographic region …

The mutant selection window hypothesis postulates that, for each antimicrobial-pathogen
combination, an antimicrobial concentration range exists in which selective amplification of …

The fluoroquinolones, a new class of potent orally absorbed antimicrobial agents, are
reviewed, considering structure, mechanisms of action and resistance, spectrum, variables …

Ciprofloxacin, considered a benchmark when comparing new fluoroquinolones, shares with
these agents a common mechanism of action: inhibition of DNA gyrase. While ciprofloxacin …

We review data on the in-vitro, ex-vivo, in-vivo, and clinical effects of fluoroquinolones on the
synthesis of cytokines and their mechanisms of immunomodulation. In general, most …

HUMAN PHARMACOLOGY OF THE FLUOROQUINOLONES The pharmacologic properties
of the fluoroquinolones have in general been determined in healthy human volun-teers …

Compared with nalidixic acid, ciprofloxacin is representative of a newer, more potent class of
quinolones, termed the fluoroquinolones. It is available in both oral and parenteral dosage …

High-performance liquid chromatographic methods for the analysis of fluoroquinolones in
biological fluids are reviewed. In particular, sample preparation and handling procedures …

The newer fluoroquinolones are a major advance in antimicrobial chemotherapy. They
inhibit the supercoiling activity of the DNA gyrase enzyme, thus exerting their antibacterial …

We evaluated the absolute bioavailability of ciprofloxacin, a new quinoline carboxylic acid,
in 12 healthy male volunteers. Doses of 200 mg were given to each of the volunteers in a …