A review of pseudorabies virus variants: genomics, vaccination, transmission, and zoonotic potential

Z Bo, X Li - Viruses, 2022 - mdpi.com
Pseudorabies virus (PRV), the causative agent of Aujeszky's disease, has a broad host
range including most mammals and avian species. In 2011, a PRV variant emerged in many …

The attenuated pseudorabies virus vaccine strain Bartha K61: a brief review on the knowledge gathered during 60 years of research

JL Delva, HJ Nauwynck, TC Mettenleiter, HW Favoreel - Pathogens, 2020 - mdpi.com
Pseudorabies virus (PRV) is a member of the alphaherpesvirus subfamily of the
herpesviruses and is the causative agent of Aujeszky's disease in pigs, causing respiratory …

Emergence of a novel pathogenic recombinant virus from Bartha vaccine and variant pseudorabies virus in China

Z Bo, Y Miao, R Xi, X Gao, D Miao… - Transboundary and …, 2021 - Wiley Online Library
Pseudorabies virus (PRV), the causative agent of Aujeszky's disease, has resulted in
substantial economic losses in the swine industry worldwide. Previous reports have shown …

Analysis of the recombination and evolution of the new type mutant pseudorabies virus XJ5 in China

L Jiang, J Cheng, H Pan, F Yang, X Zhu, J Wu, H Pan… - BMC genomics, 2024 - Springer
Pseudorabies have caused enormous economic losses in China's pig industry and have
recurred on many large pig farms since late 2011. The disease is caused by highly …

Glycoproteins C and D of PRV strain HB1201 contribute individually to the escape from Bartha-K61 vaccine-induced immunity

J Ren, H Wang, L Zhou, X Ge, X Guo, J Han… - Frontiers in …, 2020 - frontiersin.org
The newly emerged pseudorabies virus (PRV) novel variants can escape from the immunity
induced by the classical vaccine Bartha-K61. Here we investigated the underlying …

Isolation and identification of two novel pseudorabies viruses with natural recombination or TK gene deletion in China

Y Qin, S Qin, X Huang, L Xu, K Ouyang, Y Chen… - Veterinary …, 2023 - Elsevier
Pseudorabies virus (PRV), the causative agent of Aujeszky's disease, has gained increased
attention in China in recent years due to outbreaks of emergent pseudorabies. However …

Pseudorabies virus induces autophagy to enhance viral replication in mouse neuro-2a cells in vitro

C Xu, M Wang, Z Song, Z Wang, Q Liu, P Jiang, J Bai… - Virus research, 2018 - Elsevier
Autophagy of cytoplasmic components plays an essential role in the pathogenic infection
process. Furthermore, research suggests that autophagy is an extremely important …

Construction of a quadruple gene-deleted vaccine confers complete protective immunity against emerging PRV variant challenge in piglets

L Sun, Y Tang, K Yan, H Zhang - Virology Journal, 2022 - Springer
Background Pseudorabies virus (PRV) causes Aujeszky's disease or pseudorabies (PR) in
pigs worldwide, which leads to heavy economic losses to the swine industry. Pigs are the …

Isolation and characterization of two pseudorabies virus and evaluation of their effects on host natural immune responses and pathogenicity

Q Zhou, L Zhang, H Liu, G Ye, L Huang, C Weng - Viruses, 2022 - mdpi.com
Pseudorabies, caused by the pseudorabies virus (PRV), is an acute fatal disease, which can
infect rodents, mammals, and other livestock and wild animals across species. Recently, the …

Effective cross-protection of a lyophilized live gE/gI/TK-deleted pseudorabies virus (PRV) vaccine against classical and variant PRV challenges

Y Sun, L Zhao, ZF Fu - Veterinary Microbiology, 2022 - Elsevier
Classical Bartha-K61 strains could not provide complete protection against the emerging
highly virulent pseudorabies virus (PRV) variant strains, which has caused great economic …