Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation, but also dormancy and cellular …

Abstract NECTIN-4 [a poliovirus receptor-related-4 (pvrl-4) encoded protein] is a Ca 2+
independent immunoglobulin-like protein. Along with other Nectins (Nectin-1,-2 and-3), it is …

Background Breast cancer stem cells (BCSCs) have a critical role in progression of breast
cancer by inducing angiogenesis. Several therapeutic strategies have been designed for the …

The Nectin cell adhesion protein 4 (Nectin-4) is overexpressed in multiple human
malignancies. Such aberrant expression is correlated with cancer progression and poor …

Concurrent use of DNA damaging agents with PARP inhibitors contribute to the
effectiveness of the anticancer therapy. But there is a dearth of reports on the antiangiogenic …

Although sensitization of BRCA-mutated, homologous recombination (HR)-deficient breast
cancer cells through PARP inhibitor is widely studied, not much is known about the …

Tumor-induced lymphangiogenesis promotes tumor progression by generating new
lymphatic vessels that helps in tumor dissemination to regional lymph nodes and distant …

Cervical cancer is one of the most diagnosed malignancies among females. The 5-
fluorouracil (5-Fu) is a widely used chemotherapeutic agent against diverse cancers …