Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …

Abstract 293 cell line (widely known as the Human Embryonic Kidney 293 cells) and its
derivatives were the most used cells after HeLa in cell biology studies and after CHO in …

Metastasis—the disseminated growth of tumours in distant organs—underlies cancer
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …

Synaptogenesis, the generation and maturation of functional synapses between nerve cells,
is an essential step in the development of neuronal networks in the brain. It is thought to be …

Neurexins and neuroligins are emerging as central organizing molecules for excitatory
glutamatergic and inhibitory GABAergic synapses in mammalian brain. They function as cell …

The normal function of neural networks depends on a delicate balance between excitatory
and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional …

Previous studies suggested that postsynaptic neuroligins form a trans-synaptic complex with
presynaptic β-neurexins, but not with presynaptic α-neurexins. Unexpectedly, we now find …

Delineating the molecular basis of synapse development is crucial for understanding brain
function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse …

A number of synaptogenic factors induce presynaptic or postsynaptic differentiation when
presented to axons or dendrites. Many such factors participate in bidirectional trans-synaptic …

The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …