Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Vitamin K–sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity

P Mladěnka, K Macáková, L Kujovská Krčmová… - Nutrition …, 2022 - academic.oup.com
Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also …

Cardiovascular calcification heterogeneity in chronic kidney disease

JD Hutcheson, C Goettsch - Circulation Research, 2023 - Am Heart Assoc
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for
cardiovascular disease, particularly ischemic heart disease, due to premature vascular and …

Vitamin E: How much is enough, too much and why!

MG Traber, B Head - Free Radical Biology and Medicine, 2021 - Elsevier
Abstract α-Tocopherol (α-T) is a required dietary nutrient for humans and thus is a vitamin.
This narrative review focuses on vitamin E structures, functions, biological determinants and …

Vitamin K‑dependent proteins involved in bone and cardiovascular health

L Wen, J Chen, L Duan, S Li - Molecular medicine …, 2018 - spandidos-publications.com
In postmenopausal women and elderly men, bone density decreases with age and vascular
calcification is aggravated. This condition is closely associated with vitamin K2 deficiency. A …

Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease

AMG Jaminon, L Dai, AR Qureshi, P Evenepoel… - Scientific reports, 2020 - nature.com
Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires
carboxylation by vitamin K to exert calcification inhibition. Chronic kidney disease (CKD) …

Association of the inactive circulating matrix Gla protein with vitamin K intake, calcification, mortality, and cardiovascular disease: a review

S Roumeliotis, E Dounousi, T Eleftheriadis… - International journal of …, 2019 - mdpi.com
Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful
natural occurring inhibitor of calcification in the human body. To become biologically active …

The inhibitory roles of vitamin K in progression of vascular calcification

A Shioi, T Morioka, T Shoji, M Emoto - Nutrients, 2020 - mdpi.com
Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-
dependent proteins (VKDPs) and may be implicated in cardiovascular disease (CVD) …

Vitamin K plasma levels determination in human health

M Fusaro, M Gallieni, MA Rizzo, A Stucchi… - Clinical Chemistry and …, 2017 - degruyter.com
Vitamin K (phylloquinone or vitamin K1 and menaquinones or vitamin K2) plays an
important role as a cofactor in the synthesis of hepatic blood coagulation proteins, but …

Vitamin K as a powerful micronutrient in aging and age-related diseases: pros and cons from clinical studies

DC Simes, CSB Viegas, N Araújo… - International journal of …, 2019 - mdpi.com
Vitamin K is a multifunctional micronutrient implicated in age-related diseases such as
cardiovascular diseases, osteoarthritis and osteoporosis. Although vitamin K-dependent …