Urticaria

P Kolkhir, AM Giménez-Arnau, K Kulthanan… - Nature Reviews …, 2022 - nature.com
Urticaria is an inflammatory skin disorder that affects up to 20% of the world population at
some point during their life. It presents with wheals, angioedema or both due to activation …

Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances

A Kaplan, M Lebwohl, AM Giménez‐Arnau, M Hide… - Allergy, 2023 - Wiley Online Library
Chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by
intensely itchy wheals, angioedema, or both. Symptoms recur spontaneously, on a near …

Chronic urticaria and the pathogenic role of mast cells

D Elieh-Ali-Komi, M Metz, P Kolkhir… - Allergology …, 2023 - jstage.jst.go.jp
abstract The signs and symptoms of chronic urticaria (CU) are caused by the activation and
degranulation of skin mast cells (MCs). Recent studies have added to our understanding of …

Chronic spontaneous urticaria: the role and relevance of autoreactivity, autoimmunity, and autoallergy

R Asero, M Ferrer, E Kocaturk, M Maurer - The Journal of Allergy and …, 2023 - Elsevier
Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A
large number of studies were performed during the last 2 decades to clarify its pathogenesis …

Most patients with autoimmune chronic spontaneous urticaria also have autoallergic urticaria, but not vice versa

YK Xiang, P Kolkhir, J Scheffel, M Sauer, C Vera… - The Journal of Allergy …, 2023 - Elsevier
Background Two endotypes of chronic spontaneous urticaria (CSU) associated with mast
cell–activating autoantibodies are described, namely autoallergic chronic spontaneous …

Urticaria and angioedema: understanding complex pathomechanisms to facilitate patient communication, disease management, and future treatment

GN Konstantinou, MA Riedl, P Valent, I Podder… - The Journal of Allergy …, 2023 - Elsevier
Chronic spontaneous urticaria (CSU) is primarily a T2-dominant disease with a complex
genetic background. Skin mast cell activation can be induced not only via the IgE-FcεRI axis …

Immunoglobulin E autoantibodies in atopic dermatitis associate with Type‐2 comorbidities and the atopic march

I Kortekaas Krohn, FMS Badloe, N Herrmann… - Allergy, 2023 - Wiley Online Library
Abstract Background Autoreactive immunoglobulin E (IgE) antibodies to self‐peptides within
the epidermis have been identified in patients with atopic dermatitis (AD). Prevalence …

How infection and vaccination are linked to acute and chronic urticaria: a special focus on COVID-19

E Kocatürk, M Muñoz, D Elieh-Ali-Komi, PR Criado… - Viruses, 2023 - mdpi.com
Since more than a century ago, there has been awareness of the connection between viral
infections and the onset and exacerbation of urticaria. Our knowledge about the role of viral …