Fibroblasts are present throughout the body and function to maintain tissue homeostasis.
Recent studies have identified diverse fibroblast subsets in healthy and injured tissues,, but …

Vascular endothelium plays a crucial role in vascular homeostasis and tissue fluid balance.
To target endothelium for robust genome editing, we developed poly (ethylene glycol) …

Abstract Persons with the Ehlers–Danlos syndromes (EDS) report a wide range of
respiratory symptoms, most commonly shortness of breath, exercise limitation, and cough …

Objectives. As the central organ of the respiratory system, the human lung is responsible for
supplying oxygen to the blood, which reaches the erythrocytes by diffusion through the …

Lung diseases develop when telomeres shorten beyond a critical point. We constructed a
mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive …

Electronic cigarette (e-cig) use has increased over the past decade, and exposure to e-cig
aerosols during pregnancy raises concern for maternal and fetal health. The developing …

Clinical observation indicates that exercise capacity, an important determinant of survival in
patients with congenital heart disease (CHD), is most decreased in children with reduced …

Fibroblasts substantially remodel extracellular matrix (ECM) in response to tissue injury and
generate fibrotic scars in chronic diseases. Recent studies have identified diverse fibroblast …

We investigated Hippo signaling pathway components in emphysema development of air
pollution-exposed ageing rats. Male 1.5-year-old Fischer 344 ageing rats were exposed to …

Oligohydramnios (decreased amniotic fluid volume for gestational age) is a severe condition
associated with high morbidity and mortality mainly due to fetal pulmonary hypoplasia …