Systems analysis of thrombus formation

SL Diamond - Circulation research, 2016 - Am Heart Assoc
The systems analysis of thrombosis seeks to quantitatively predict blood function in a given
vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a …

High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis

Y Wang, J Qiu, S Luo, X Xie, Y Zheng… - Regenerative …, 2016 - academic.oup.com
Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary
syndrome and ischemic strokes. Inhibition of thrombosis is one of the important tasks …

The importance of blood rheology in patient-specific computational fluid dynamics simulation of stenotic carotid arteries

JB Mendieta, D Fontanarosa, J Wang… - … and Modeling in …, 2020 - Springer
The initiation and progression of atherosclerosis, which is the main cause of cardiovascular
diseases, correlate with local haemodynamic factors such as wall shear stress (WSS) …

Fluid–structure interaction analysis of a patient‐specific right coronary artery with physiological velocity and pressure waveforms

R Torii, NB Wood, N Hadjiloizou… - Communications in …, 2009 - Wiley Online Library
Coupled fluid–structure interaction (FSI) analysis of the human right coronary artery (RCA)
has been carried out to investigate the effects of wall compliance on coronary …

[HTML][HTML] On the nonlinear relationship between wall shear stress topology and multi-directionality in coronary atherosclerosis

HJ Carpenter, MH Ghayesh, AC Zander… - Computer Methods and …, 2023 - Elsevier
Abstract Background and Objective In this paper we investigate twelve multi-
directional/topological wall shear stress (WSS) derived metrics and their relationships with …

[HTML][HTML] Numerical analysis of the effect of turbulence transition on the hemodynamic parameters in human coronary arteries

A Mahalingam, UU Gawandalkar, G Kini… - Cardiovascular …, 2016 - ncbi.nlm.nih.gov
Background Local hemodynamics plays an important role in atherogenesis and the
progression of coronary atherosclerosis disease (CAD). The primary biological effect due to …

Coronary arteries hemodynamics: effect of arterial geometry on hemodynamic parameters causing atherosclerosis

KKL Wong, J Wu, G Liu, W Huang… - Medical & biological …, 2020 - Springer
Coronary arteries have high curvatures, and hence, flow through them causes disturbed flow
patterns, resulting in stenosis and atherosclerosis. This in turn decreases the myocardial …

Direct observation of von Willebrand factor elongation and fiber formation on collagen during acute whole blood exposure to pathological flow

TV Colace, SL Diamond - Arteriosclerosis, thrombosis, and …, 2013 - Am Heart Assoc
Objective—In severe stenosis, von Willebrand Factor (vWF) experiences millisecond
exposures to pathological wall shear rates (γw). We sought to evaluate the deposition of …

Effect of stenosis and dilatation on the hemodynamic parameters associated with left coronary artery

S Sandeep, SR Shine - Computer Methods and Programs in Biomedicine, 2021 - Elsevier
Abstract Background and Objective: The main objective of the work is to examine the
curvature effects of stenosis/dilatation region pertaining to left coronary artery. The …

Arterial pressure and flow wave analysis using time-domain 1-D hemodynamics

M Willemet, J Alastruey - Annals of biomedical engineering, 2015 - Springer
We reviewed existing methods for analyzing, in the time domain, physical mechanisms
underlying the patterns of blood pressure and flow waveforms in the arterial system. These …