Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

Compared with rapid accumulation of protein sequences from high-throughput DNA
sequencing, obtaining experimental 3D structures of proteins is still much more difficult …

Making up over 92% of life in our oceans, marine invertebrates inhabit every zone in the
water column, with contributions ranging from ecosystem functioning to socioeconomic …

Toxins are substances produced from biological sources (eg, animal, plants,
microorganisms) that have deleterious effects on a living organism. Despite the obvious …

Snails can provide a considerable variety of bioactive compounds for cosmetic and
pharmaceutical industries, useful for the development of new formulations with less toxicity …

Bioactive peptides are a highly abundant and diverse group of molecules that exhibit a wide
range of structural and functional variation. Despite their immense therapeutic potential …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes,
centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active …

For decades, ibogaine─ the main psychoactive alkaloid found in Tabernanthe iboga─ has
been investigated as a possible treatment for substance use disorders (SUDs) due to its …