The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

Any tissue is made up of a heterogeneous mix of spatially distributed cell types. In response
to any (patho) physiological cue, responses of each cell type in any given tissue may be …

The objective of this study was to examine FoxO expression and FoxO function in meniscus.
In menisci from human knee joints with osteoarthritis (OA), FoxO1 and 3 expression were …

The objective of this study was to investigate whether meniscus-derived decellularized
matrix (DCM) has the capacity to induce differentiation of synovial fluid-derived …

Meniscus injuries are extremely common with approximately one million patients
undergoing surgical treatment annually in the US alone. Upon injury, the outer zone of the …

Meniscus tears are common knee injuries and a major osteoarthritis (OA) risk factor.
Knowledge gaps that limit the development of therapies for meniscus injury and …

Rotator cuff injuries present a clinical challenge for repair due to current limitations in
functional regeneration of the native tendon-to-bone enthesis. A biomaterial that can …

Both the WNT/β-catenin and hedgehog signaling pathways are important in the regulation of
limb development, chondrocyte differentiation, and degeneration of articular cartilage in …

Bone morphogenetic proteins (BMPs) are key regulators of skeletal development, growth,
and repair. Although BMP signaling is required for synovial joint formation and is also …

Understanding early patterning events in the extracellular matrix (ECM) formation can
provide a blueprint for regenerative strategies to better recapitulate the function of native …