Excessive cellular oxidative stress is widely perceived as a key factor in pathophysiological
conditions and cancer development. Healthy cells use several mechanisms to maintain …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Reactive oxygen species (ROS), whether produced endogenously as a consequence of
normal cell functions or derived from external sources, pose a constant threat to cells living …

Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on
inflammation and play a key role in the regulation of immune responses. They affect virtually …

Cell survival requires multiple factors, including appropriate proportions of molecular oxygen
and various antioxidants. Although most oxidative insults can be overcome by the cell's …

NF-κB in defense and disease ciated with inflammatory disease. Indeed, as discussed by
Tak and Firestein (this Perspective series), NF-κB is activated in the inflamed synovium of …

Apoptosis is a physiological process critical for organ development, tissue homeostasis, and
elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can …

Salvia officinalis L. can be found worldwide and its leaves are commonly used as ingredient
in food industry. Sage essential oil is applied in the treatment of a range of diseases and has …

NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …

Chronic systemic complex I inhibition caused by rotenone exposure induces features of
Parkinson's disease (PD) in rats, including selective nigrostriatal dopaminergic …