Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display
peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells. Like …

Studies carried out during the last few decades have consistently shown that cell surface
MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen …

Intercellular communication is crucial for collective regulation of cellular behaviors. While
clustering T cells have been shown to mutually control the production of key communication …

Highlights•MHC class I constitutively traffics between the endosomal system and the
surface.•Within endosomes, MHC class I assembles with both endogenous and exogenous …

Immunotherapy has changed the treatment landscape for multiple cancer types. In the
recent decade, great progress has been made in immunotherapy, including immune …

For any nonautonomous dynamical system, the family of Koopman operators, as well as
related Koopman eigenvalues and eigenfunctions, is parameterized by a time pair …

Extracellular vesicles (EVs) are membranous nanostructures that can indicate undergoing
processes in organs and thus help in diagnostics and prognostics. They are secreted by all …

Immune checkpoint blockade (ICB) therapy has achieved broad applicability and durable
clinical responses across cancer types. However, the overall response rate remains …

Cytomegalovirus (CMV) infection initiates massive rearrangement of cytoplasmic organelles
to generate assembly compartment (AC). The earliest events, the establishment of the …

Phosphatidylinositol-3-phosphate (PI3P), a major identity tag of early endosomes (EEs),
provides a platform for the recruitment of numerous cellular proteins containing an FYVE or …