Crk family adaptors are widely expressed and mediate the timely formation of signal
transduction protein complexes upon a variety of extracellular stimuli, including various …

Interferons are pleiotropic cytokines that exhibit negative regulatory effects on the growth of
normal and malignant hematopoietic cells in vitro and in vivo. There are two different classes …

Activation of mitogen-activated protein (MAP) kinase (also known as extracellular-signal-
regulated kinase, or ERK) by growth factors can trigger either cell growth or differentiation …

Carcinoma cells selected for their ability to migrate in vitro showed enhanced invasive
properties in vivo. Associated with this induction of migration was the anchorage-dependent …

CRK belongs to a family of adaptor proteins that consist mostly of SH2 and SH3 domains.
Far Western blotting with CRK SH3 has demonstrated that it binds to 135-to 145-, 160-, and …

Integrin-mediated cell adhesion triggers intracellular signaling cascades, including tyrosine
phosphorylation of intracellular proteins. Among these are the focal adhesion proteins p130 …

The Drosophila myoblast city (mbc) locus was previously identified on the basis of a defect
in myoblast fusion (. Development [Camb.]. 121: 1979–1988). We describe herein the …

Tyrosine kinase oncogenes are formed as a result of mutations that induce constitutive
kinase activity. Many of these tyrosine kinase oncogenes that are derived from genes, such …

The protein product of the c-Cbl proto-oncogene is prominently tyrosine phosphorylated in
response to insulin in 3T3-L1 adipocytes and not in 3T3-L1 fibroblasts. After insulin …

The CRKL adaptor protein was recently identified as a substrate for the BCR-ABL tyrosine
kinase in patients with chronic myelogenous leukemia, but its function is unknown. Here we …