Homopolymeric stretches of deoxyadenosine nucleotides (A's) on one strand of double-
stranded DNA, referred to as poly (dA: dT) tracts or A-tracts, are overabundant in eukaryotic …

Short runs of adenines are a ubiquitous DNA element in regulatory regions of many
organisms. When runs of 4–6 adenine base pairs ('A-tracts') are repeated with the helical …

The principal sequence feature responsible for intrinsic DNA curvature is generally assumed
to be runs of adenines. However, according to the wedge model of DNA curvature, each …

A simple program, BEND, has been written to calculate the magnitude of local bending and
macroscopic curvature at each point along an arbitrary B-DNA sequence, using any desired …

Intrinsically bent or curved DNA molecules result when special base sequences or structural
motifs are repeated in phase with the DNA helical repeat (~ 10.5 bp'/turn). This places the …

Abstract Poly (dA–dT)· poly (dA–dT) is a double‐helical B DNA containing A· T and T· A
base pairs in alternating sequence. Although Raman spectra of this structure have been …

Revised Manuscript Received May 14, 1990 abstract: The validity of a theoretical nearest-
neighbor model based on conformational energy calculations, for translating the …

Sequence-specific protein-DNA interactions are at the heart of the response of the tumor-
suppressor p53 to numerous physiological and stress-related signals. Large variability has …

The Gram‐negative, curved rod Vibrio cholerae causes the severe diarrhoeal disease
cholera. The two major virulence factors produced by V. cholerae during infection are the …

Crystallographic studies of duplex DNA have indicated that opposing exocyclic amino
groups may form close NH⋯ N contacts. To study the nature of such interactions, we have …