Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

Antibodies are key reagents to investigate cellular processes. The development of
recombinant antibodies and binders derived from natural protein scaffolds has expanded …

Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with
different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs) …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Centrosomes—as well as the related spindle pole bodies (SPBs) of yeast—have been
extensively studied from the perspective of their microtubule-organizing roles. Moreover, the …

Centrioles are required to assemble centrosomes for cell division and cilia for motility and
signalling. New centrioles assemble perpendicularly to pre-existing ones in G1–S and …

Centrosome amplification results into genetic instability and predisposes cells to neoplastic
transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the …

Polarization is a fundamental cellular property, which is essential for the function of
numerous cell types. Over the past three to four decades, research using the best …

Cells can, in principle, control their size by growing to a specified size before commencing
cell division. How any cell actually senses its own size remains poorly understood. The …