The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

Initially developed in the mid-1990s to examine the conformational changes of the canonical
Shaker voltage-gated potassium channel, functional site-directed fluorometry has since …

We report on a heterozygous KCNA2 variant in a child with epilepsy. KCNA2 encodes KV1.
2 subunits, which form homotetrameric potassium channels and participate in …

Key points KV1. 2 channels, encoded by the KCNA2 gene, regulate neuronal excitability by
conducting K+ upon depolarization. A new KCNA2 missense variant was discovered in a …

Kv1. 2 is a prominent potassium channel subtype in the nervous system and serves as an
important structural template for investigation of ion channel function. However, Kv1. 2 …

Large-conductance voltage-and Ca2+-activated K+ (BKCa) channel α subunits possess a
unique transmembrane helix referred to as S0 at their N terminus, which is absent in other …

We systematically predict the internal flexibility of the S3 segment, one of the most mobile
elements in the voltage-sensor domain. By analyzing the primary amino acid sequences of …

The mechanism by which voltage-gated ion channels respond to changes in membrane
polarization during action potential signaling in excitable cells has been the subject of …

Kv2. 1 channels exhibit a U-shaped voltage-dependence of inactivation that is thought to
represent preferential inactivation from preopen closed states. However, the molecular …

How a protein propagates the conformational changes throughout its structure remains
largely unknown. In thermosensitive TRP channels, this allosteric communication is …