Conspectus Decades after its discovery, positron emission tomography (PET) remains the
premier tool for imaging neurochemistry in living humans. Technological improvements in …

Despite recent advances in multimodality therapy for glioblastoma (GB) incorporating
surgery, radiotherapy, chemotherapy and targeted therapy, the overall prognosis remains …

BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits.
Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the …

Age-and sex-related alterations in gene transcription have been demonstrated, however the
underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene …

Aims Alzheimer's disease (AD) is characterized by degeneration of cholinergic basal
forebrain (CBF) neurons in the nucleus basalis of Meynert (nbM), which provides the major …

Although the frontal cortex plays an important role in cognitive function and undergoes
neuronal dysfunction in Alzheimer's disease (AD), the factors driving these cellular …

There is increasing evidence that a number of potentially informative biomarkers for
Alzheimer disease (AD) can improve the accuracy of diagnosing this form of dementia …

Postmortem brain studies support dysregulated expression of the histone deacetylase
enzymes, HDAC1 and HDAC2, as a central feature in diseases including schizophrenia …

The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are
not fully understood. Both genetic and environmental factors contribute to the risk of BD …

To develop novel CNS penetrant HDAC inhibitors, a new series of HDAC inhibitors having
benzoheterocycle were designed, synthesized, and biologically evaluated. Among the …