Biosensors for detecting macromolecules and other analytes

T Heyduk, E Heyduk, E Knoll - US Patent 7,939,313, 2011 - Google Patents
Introduction he inventors of the instant invention have developed a methodology for
detecting DNA binding proteins, as described in Heyduk, T. and Heyduk, E.“Molecular …

Riboswitches, methods for their use, and compositions for use with riboswitches

RR Breaker, A Nahvi, N Sudarsan, MS Ebert… - US Patent …, 2010 - Google Patents
2003-12-29 Assigned to YALE UNIVERSITY reassignment YALE UNIVERSITY
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same

AK Agarwal, VK Goel, DS Kim, B Lin… - US Patent …, 2020 - Google Patents
A biosensor device for the real-time detection of a target analyte includes a receptor
component operatively connected to a transducer component which is adapted to interpret …

3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing

W Wu, VA Litosh, BP Stupi, ML Metzker - US Patent 7,897,737, 2011 - Google Patents
Provided are novel nucleotides, nucleoside, and their deriva tives described herein, that can
be used in DNA sequencing technology and other types of DNA analysis. In one embodi …

Real-time pcr of targets on a micro-array

J Remacle, I Alexandre, S De Roeck… - US Patent App. 12 …, 2012 - Google Patents
US20120053068A1 - Real-time pcr of targets on a micro-array - Google Patents US20120053068A1
- Real-time pcr of targets on a micro-array - Google Patents Real-time pcr of targets on a …

3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing

BP Stupi, H Li, W Wu, MN Hersh, D Hertzog… - US Patent …, 2016 - Google Patents
2018-09-21 Assigned to LASERGEN, INC. reassignment LASERGEN, INC. ASSIGNMENT
OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HERTZOG …

Molecular biosensors for use in competition assays

T Heyduk, L Tian - US Patent 7,811,809, 2010 - Google Patents
This methodology is based on splitting the DNA binding site of proteins into two DNA “half-
sites.” Each of the resulting “half-sites” contains a short complementary single-stranded …

Photocleavable labeled nucleotides and nucleosides and methods for their use in DNA sequencing

W Wu, VA Litosh, BP Stupi… - US Patent App. 11/567,189, 2008 - Google Patents
BACKGROUND 0002 Methods for rapidly sequencing DNA have become needed for
analyzing diseases and mutations in the popula tion and developing therapies. The most …

Sensor systems for measuring an interface level in a multi-phase fluid composition

CM Surman, WC Platt, WG Morris, S Go… - US Patent …, 2017 - Google Patents
3,675,121 A 7/1972 Thompson 3,778,706 A 12/1973 Thompson 3,927,369 A 12/1975
Billeter et al. 4,096,385 A 6, 1978 Marett et al. 4,273,636 A 6, 1981 Shimada et al. 4,275,364 …

Apparatus for detecting contaminants in a liquid and a system for use thereof

RA Potyrailo, DJ Monk, R Tamaki - US Patent 9,589,686, 2017 - Google Patents
Disclosed herein are apparatus and methods for detecting and quantifying contaminants in
aqueous solutions. In one embodiment, an apparatus for the detection of contaminants …