In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom …

Mps1 is an essential component of the spindle assembly checkpoint. In this study, we
describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of Mps1's catalytic …

For over a century, scientists have strived to understand the mechanisms that govern the
accurate segregation of chromosomes during mitosis. The most intriguing feature of this …

The Ndc80 complex is a key site of regulated kinetochore–microtubule attachment (a
process required for cell division), but the molecular mechanism underlying its function …

The spindle checkpoint is a conserved signaling pathway that ensures genomic integrity by
preventing cell division when chromosomes are not correctly attached to the spindle …

Prostate cancer (PCa) accounts for a high number of deaths in males with no available
curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to …

Kinetochores play an essential role in chromosome segregation by forming dynamic
connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore …

The kinetochore is a control module that both powers and regulates chromosome
segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably …