The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation
AM Grabiec, T Hussell - Seminars in immunopathology, 2016 - Springer
Acute and chronic inflammatory responses in the lung are associated with the accumulation
of large quantities of immune and structural cells undergoing apoptosis, which need to be …
of large quantities of immune and structural cells undergoing apoptosis, which need to be …
Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
[HTML][HTML] Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is emerging as a leading cause of chronic liver
disease. However, therapeutic options are limited by incomplete understanding of the …
disease. However, therapeutic options are limited by incomplete understanding of the …
Lupus nephritis biomarkers: a critical review
FK Alduraibi, GC Tsokos - International Journal of Molecular Sciences, 2024 - mdpi.com
Lupus nephritis (LN), a major complication in individuals diagnosed with systemic lupus
erythematosus, substantially increases morbidity and mortality. Despite marked …
erythematosus, substantially increases morbidity and mortality. Despite marked …
Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK
C Bernsmeier, OT Pop, A Singanayagam… - Gastroenterology, 2015 - Elsevier
Background & Aims Characteristics of decompensated cirrhosis and acute-on-chronic liver
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction …
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction …
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation
The acute inflammatory response requires a coordinated resolution program to prevent
excessive inflammation, repair collateral damage, and restore tissue homeostasis, and …
excessive inflammation, repair collateral damage, and restore tissue homeostasis, and …
MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity
Inflammation resolution counterbalances excessive inflammation and restores tissue
homeostasis after injury. Failure of resolution contributes to the pathology of numerous …
homeostasis after injury. Failure of resolution contributes to the pathology of numerous …
The monocyte to macrophage transition in the murine sterile wound
MJ Crane, JM Daley, O van Houtte, SK Brancato… - PloS one, 2014 - journals.plos.org
The origin of wound repair macrophages is incompletely defined and was examined here in
sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in …
sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in …
Myeloid cell–derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10
A Maimon, V Levi-Yahid, K Ben-Meir… - The Journal of …, 2021 - Am Soc Clin Investig
Stimulation of TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases promotes tumor
progression through numerous cellular mechanisms. TAM cognate ligands GAS6 and …
progression through numerous cellular mechanisms. TAM cognate ligands GAS6 and …
Axl and Mertk receptors cooperate to promote breast cancer progression by combined oncogenic signaling and evasion of host antitumor immunity
Despite the promising clinical benefit of targeted and immune checkpoint blocking
therapeutics, current strategies have limited success in breast cancer, indicating that …
therapeutics, current strategies have limited success in breast cancer, indicating that …