Cancer is a complex disease involving numerous biological processes, which can exist in
parallel, can be complementary, or are engaged when needed and as such can replace …

P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the
body and is responsible for limiting cellular uptake and the distribution of xenobiotics and …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

Multidrug resistance in cancer is linked to expression of the P-glycoprotein multidrug
transporter (Pgp, ABCB1), which exports many structurally diverse compounds from cells …

Membrane permeability and P-glycoprotein (Pgp) can be limiting factors for blood-brain
barrier penetration. The objectives of this study were to determine whether there are …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of
compounds. Thus, identification of compounds that are Pgp substrates can aid drug …