Alzheimer disease is a progressive dementia with unknown etiology that affects a growing
number of the aging population. Increased expression of inflammatory mediators in …

Acutely developing lesions of the brain have been highly instructive in elucidating the neural
systems underlying memory in humans and animal models. Much less has been learned …

Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …

The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …

The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis
because of the complexity of AD and the overlap of its early-stage markers with normal …

The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form
new memories. For many years, this dementia was attributed to nerve-cell death induced by …

Homeostatic plasticity may compensate for Hebbian forms of synaptic plasticity, such as long-
term potentiation (LTP) and depression (LTD), by scaling neuronal output without changing …

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …

We provide microarray data comparing genome-wide differential expression and pathology
throughout life in four lines of" amyloid" transgenic mice (mutant human APP, PSEN1, or …