Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from
other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

Abstract IMGT/V-QUEST is the highly customized and integrated system for the standardized
analysis of the immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide …

Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into
distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However …

Abstract Through the European Research Initiative on chronic lymphocytic leukemia
(CLL)(ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 (n …

The cellular origin of chronic lymphocytic leukemia (CLL) is still debated, although this
information is critical to understanding its pathogenesis. Transcriptome analyses of CLL and …

Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to
profound T-cell defects. T-cell functions also depend on co-signaling receptors, inhibitory or …

Mantle cell lymphoma (MCL) is a heterogeneous disease with most patients following an
aggressive clinical course, whereas others having an indolent behavior. We conducted an …

The discovery of almost identical or 'stereotyped'B-cell receptor immunoglobulins (BcR IG)
among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of …