The principal features and mechanisms of dopamine modulation in the prefrontal cortex

JK Seamans, CR Yang - Progress in neurobiology, 2004 - Elsevier
Mesocotical dopamine (DA) inputs to the prefrontal cortex (PFC) play a crtical role in normal
cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of …

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

EN Holly, KA Miczek - Psychopharmacology, 2016 - Springer
Aversive events rapidly and potently excite certain dopamine neurons in the ventral
tegmental area (VTA), promoting phasic increases in the medial prefrontal cortex and …

The neurobiology and control of anxious states

MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain

F Mora, G Segovia, A del Arco - Brain research reviews, 2007 - Elsevier
Cajal was probably the first neurobiologist to suggest that plasticity of nerve cells almost
completely disappeared during aging. However, we know today that neural plasticity is still …

Stress, neurotransmitters, corticosterone and body–brain integration

F Mora, G Segovia, A Del Arco, M de Blas, P Garrido - Brain research, 2012 - Elsevier
Stress can be defined as a brain–body reaction towards stimuli arising from the environment
or from internal cues that are interpreted as a disruption of homeostasis. The organization of …

Neuromodulation in Tourette syndrome: dopamine and beyond

J Buse, K Schoenefeld, A Münchau… - … & Biobehavioral Reviews, 2013 - Elsevier
Almost since the beginning of research on Tourette syndrome (TS), tics have been linked to
a dysfunction of the dopamine (DA) system. At first, this assumption was mainly based on …

The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems

A Adell, F Artigas - Neuroscience & Biobehavioral Reviews, 2004 - Elsevier
The release of dopamine in the ventral tegmental area (VTA) plays an important role in the
autoinhibition of the dopamine neurons of the mesocorticolimbic system through the …

Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic …

M Möller, JL Du Preez, R Emsley, BH Harvey - European …, 2011 - Elsevier
Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to
schizophrenia. We studied the effects of 8weeks SIR on cortico-striatal redox and social and …

Environmental enrichment, prefrontal cortex, stress, and aging of the brain

G Segovia, A Arco, F Mora - Journal of neural transmission, 2009 - Springer
As a result of living in an enriched environment, the brain of animals undergoes molecular
and morphological changes leading to improvements in learning and memory. These …

Stress, prefrontal cortex and environmental enrichment: studies on dopamine and acetylcholine release and working memory performance in rats

A Del Arco, G Segovia, P Garrido, M de Blas… - Behavioural brain …, 2007 - Elsevier
The aim of the present study was to investigate whether environmental enrichment changes
the effects of acute stress on both the release of dopamine and acetylcholine in the …