Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying …

The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators
of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal …

Mutation in either of the genes encoding bone morphogenetic protein (BMP) 8A or 8B
(Bmp8a or Bmp8b) causes postnatal depletion of spermatogonia in mice. We found that …

The kinase haspin phosphorylates histone H3 at threonine-3 (H3T3ph) during mitosis.
H3T3ph provides a docking site for the Chromosomal Passenger Complex at the …

Hypoxia is a global environmental concern and poses a significant threat to aquatic
ecosystems, including the sustainability of natural fish populations. The deleterious effects of …

Male factor infertility is a problem in today's society but many underlying causes are still
unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) …

Meiotic arrest is a common cause of human male infertility, but the causes of this arrest are
poorly understood. Transactive response DNA-binding protein of 43 kDa (TDP-43) is highly …

Evidences suggest that maternal exposure to endocrine disruptor insecticide cypermethrin
(CYP) affects the reproductive functions of offspring. However, its molecular effects are not …

Cryopreservation of spermatogonial stem cells (SSCs) is essential for preservation of
valuable livestock and clinical applications. Although optimal equilibration of cryoprotectants …

Background: Recent studies revealed that some common endocrine-disrupting chemicals
(EDCs) including phthalates and phytoestrogens may exhibit low-dose effects properties …