Inhalation exposure to atmospheric nanoparticles and its associated impacts on human health: a review

S Sonwani, S Madaan, J Arora… - … in Sustainable Cities, 2021 - frontiersin.org
Nanoparticles (NPs) are receiving an increasing attention from many scientific communities
due to their strong influence on human health. NPs are an important marker of air pollution …

Inflammation and α-synuclein's prion-like behavior in Parkinson's disease—is there a link?

CM Lema Tomé, T Tyson, NL Rey, S Grathwohl… - Molecular …, 2013 - Springer
Parkinson's disease patients exhibit progressive spreading of aggregated α-synuclein in the
nervous system. This slow process follows a specific pattern in an inflamed tissue …

Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young …

L Calderón-Garcidueñas, M Kavanaugh… - Journal of …, 2012 - content.iospress.com
Air pollution exposures have been linked to neuroinflammation and neuropathology.
Autopsy samples of the frontal cortex from control (n= 8) and pollution-exposed (n= 35) …

Olfactory deposition of inhaled nanoparticles in humans

GJM Garcia, JD Schroeter, JS Kimbell - Inhalation toxicology, 2015 - Taylor & Francis
Context: Inhaled nanoparticles can migrate to the brain via the olfactory bulb, as
demonstrated in experiments in several animal species. This route of exposure may be the …

Applications of nanomaterials as vaccine adjuvants

M Zhu, R Wang, G Nie - Human vaccines & immunotherapeutics, 2014 - Taylor & Francis
Vaccine adjuvants are applied to amplify the recipient's specific immune responses against
pathogen infection or malignancy. A new generation of adjuvants is being developed to …

Microglial activation and inflammation caused by traffic-related particulate matter

KJ Bai, KJ Chuang, CL Chen, MK Jhan… - Chemico-biological …, 2019 - Elsevier
Neurotoxicity caused by particulate matter (PM) has been highlighted as being a potential
risk factor for neurodegenerative diseases. However, the effects of brain inflammation in …

Direct nose to the brain nanomedicine delivery presents a formidable challenge

RA Yokel - Wiley Interdisciplinary Reviews: Nanomedicine and …, 2022 - Wiley Online Library
This advanced review describes the anatomical and physiological barriers and mechanisms
impacting nanomedicine translocation from the nasal cavity directly to the brain. There are …

Advances in inhalation dosimetry models and methods for occupational risk assessment and exposure limit derivation

ED Kuempel, LM Sweeney, JB Morris… - … of occupational and …, 2015 - Taylor & Francis
The purpose of this article is to provide an overview and practical guide to occupational
health professionals concerning the derivation and use of dose estimates in risk assessment …

Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains

JY Ljubimova, O Braubach, R Patil, A Chiechi, J Tang… - Scientific reports, 2018 - nature.com
Air pollution is linked to brain inflammation, which accelerates tumorigenesis and
neurodegeneration. The molecular mechanisms that connect air pollution with brain …

Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory

L Tian, Y Shang, R Chen, R Bai, C Chen… - Particle and fibre …, 2019 - Springer
Background Nose-to-brain transport of airborne ultrafine particles (UFPs) via the olfactory
pathway has been verified as a possible route for particle translocation into the brain. The …