Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide
matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to …

Dental caries is one of the most common microbe-mediated oral diseases in human beings.
At present, the accepted etiology of caries is based on a four-factor theory that includes oral …

Glucosyltransferases (Gtfs) play critical roles in the etiology and pathogenesis of
Streptococcus mutans (S. mutans)-mediated dental caries including early childhood caries …

Early childhood caries (ECC) is a significant chronic disease of childhood and a rising public
health burden worldwide. ECC may cause a higher risk of new caries lesions in both primary …

Dental caries is one of the most prevalent and costly biofilm-associated infectious diseases
affecting most of the world's population. In particular, dental caries is driven by dysbiosis of …

Effective management of biofilm‐related oral infectious diseases is a global challenge. Oral
biofilm presents increased resistance to antimicrobial agents and elevated virulence …

Streptococcus mutans is a key cariogenic bacterium responsible for the initiation of tooth
decay. Biofilm formation is a crucial virulence property. We discovered a putative …

Commercial make-on-demand compound spaces have become increasingly popular within
the past few years. Since these libraries are too large for enumeration, they are usually …

The prevalence of biofilm diseases, and dental caries in particular, have encouraged
extensive research on S. mutans biofilms, including methods of preventing its formation …

Lysine acetylation is a frequently occurring post-translational modification (PTM), emerging
as an important metabolic regulatory mechanism in prokaryotes. This process is achieved …