Mechanisms of protein evolution
How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …
structure, and in turn in function? This question has multiple angles, ranging from …
Structure and function of naturally evolved de novo proteins
Highlights•Comparative evolutionary genomics has revealed that novel protein coding
genes can emerge randomly from non-coding DNA.•The existence of de novo proteins …
genes can emerge randomly from non-coding DNA.•The existence of de novo proteins …
Uncovering gene-family founder events during major evolutionary transitions in animals, plants and fungi using GenEra
Abstract We present GenEra (https://github. com/josuebarrera/GenEra), a DIAMOND-fueled
gene-family founder inference framework that addresses previously raised limitations and …
gene-family founder inference framework that addresses previously raised limitations and …
The structures of two archaeal type IV pili illuminate evolutionary relationships
We have determined the cryo-electron microscopic (cryo-EM) structures of two archaeal type
IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 Å and …
IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 Å and …
AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl‐tRNA synthetases
The aminoacyl‐tRNA synthetases (aaRS) are a large group of enzymes that implement the
genetic code in all known biological systems. They attach amino acids to their cognate …
genetic code in all known biological systems. They attach amino acids to their cognate …
Function and regulation of corin in physiology and disease
N Dong, Y Niu, Y Chen, S Sun… - Biochemical Society …, 2020 - portlandpress.com
Atrial natriuretic peptide (ANP) is of major importance in the maintenance of electrolyte
balance and normal blood pressure. Reduced plasma ANP levels are associated with the …
balance and normal blood pressure. Reduced plasma ANP levels are associated with the …
Modularity of cellulases, xylanases, and other glycosyl hydrolases relevant for biomass degradation
R Berlemont, DA Fuller, A Sudarshan - Handbook of Biorefinery Research …, 2024 - Springer
Cellulases and xylanases are glycoside hydrolases essential for the enzymatic
deconstruction of plant polysaccharides across environments and in many biotechnological …
deconstruction of plant polysaccharides across environments and in many biotechnological …
Experimental recombining of repetitive motifs leads to large functional metallothioneins and demonstrates their modular evolvability potential
R Dallinger, V Pedrini‐Martha, ML Burdisso… - Protein …, 2025 - Wiley Online Library
Protein modularity is acknowledged for promoting the emergence of new protein variants via
domain rearrangements. Metallothioneins (MTs) offer an excellent model system for …
domain rearrangements. Metallothioneins (MTs) offer an excellent model system for …
Protlego: a Python package for the analysis and design of chimeric proteins
Motivation Duplication and recombination of protein fragments have led to the highly diverse
protein space that we observe today. By mimicking this natural process, the design of protein …
protein space that we observe today. By mimicking this natural process, the design of protein …
New genomic signals underlying the emergence of human proto-genes
De novo genes are novel genes which emerge from non-coding DNA. Until now, little is
known about de novo genes' properties, correlated to their age and mechanisms of …
known about de novo genes' properties, correlated to their age and mechanisms of …