Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

Microglia, the resident immune cells in the brain, are essential for modulating neurogenesis,
influencing synaptic remodeling, and regulating neuroinflammation by surveying the brain …

Background Alcohol abuse triggers neuroinflammation, leading to neuronal damage and
further memory and cognitive impairment. Few satisfactory advances have been made in the …

Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …

Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as
Alzheimer's and Parkinson's disease. Prolonged excessive alcohol intake contributes to …

Toll-like receptors play an important role in the innate immune response, although emerging
evidence indicates their role in brain injury and neurodegeneration. Alcohol abuse induces …

Alcohol and substance abuse disorders involve continued use of substances despite
negative consequences, ie loss of behavioral control of drug use. The frontal-cortical areas …