Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

H Duan, Q Zhang, J Liu, R Li, D Wang, W Peng… - Pharmacological …, 2021 - Elsevier
Atherosclerosis, a chronic multifactorial disease, is closely related to the development of
cardiovascular diseases and is one of the predominant causes of death worldwide. Normal …

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

J Wang, S Toan, H Zhou - Angiogenesis, 2020 - Springer
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury

SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Homocysteine and mitochondria in cardiovascular and cerebrovascular systems

P Kaplan, Z Tatarkova, MK Sivonova, P Racay… - International journal of …, 2020 - mdpi.com
Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art

R Esse, M Barroso, I Tavares de Almeida… - International journal of …, 2019 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4

X Zhang, Z Huang, Z Xie, Y Chen, Z Zheng… - Free Radical Biology …, 2020 - Elsevier
Homocysteine (Hcy) is an amino acid involved in gene methylation. Plasma concentration of
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …

Folic acid supplementation in patients with elevated homocysteine levels

AD Kaye, GM Jeha, AD Pham, MC Fuller, ZI Lerner… - Advances in …, 2020 - Springer
Introduction Folic acid is the most important dietary determinant of homocysteine (Hcy). Hcy
serves as a critical intermediate in methylation reactions. It is created from methionine and …

Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis

D Yuan, J Chu, H Lin, G Zhu, J Qian, Y Yu… - Frontiers in …, 2023 - frontiersin.org
Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …

Parkinson's disease risk and hyperhomocysteinemia: the possible link

HM Al-Kuraishy, AI Al-Gareeb, YHA Elewa… - Cellular and Molecular …, 2023 - Springer
Parkinson's disease (PD) is one of the most common degenerative brain disorders caused
by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and …

Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall

B Balint, VK Jepchumba, JL Guéant… - Biochimie, 2020 - Elsevier
Homocysteine (Hcy) is a non-protein forming amino acid which is the direct metabolic
precursor of methionine. Increased concentration of serum Hcy is considered a risk factor for …