The third-generation tyrosine kinase inhibitors (TKI), AZD9291 (osimertinib) and CO-1686
(rociletinib) of epidermal growth factor receptor (EGFR) are highly active against T790M …

An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes
predictive of outcome, improving diagnostic precision beyond clinical descriptors such as …

Background Angiogenesis is a hallmark of cancer and plays a critical role in lung cancer
progression, which involves interactions between cancer cells, endothelial cells and the …

In this study, we established the predictive model for lung adenocarcinoma (LUAD)
depending on immune-related gene pairs (IRGPs) signature, which could not consider the …

Background Lung cancer is the leading cause of the largest number of deaths worldwide
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …

Lung cancer is the second most frequently diagnosed cancer type and responsible for the
highest number of cancer deaths worldwide. Lung adenocarcinoma (LUAD) and lung …

Due to the high heterogeneity of lung adenocarcinoma (LUAD), molecular subtype based on
gene expression profiles is of great significance for diagnosis and prognosis prediction in …

Precise biomarker development is a key step in disease management. However, most of the
published biomarkers were derived from a relatively small number of samples with …

Lung Cancer remains the leading cause of cancer deaths in the USA and worldwide. Non-
small cell lung cancer (NSCLC) harbors high transcriptomic intratumor heterogeneity (RNA …

The survival rate of patients with lung adenocarcinoma (LUAD) is low. This study analyzed
the correlation between the expression of long noncoding RNA (lncRNA) and epigenetic …