Cutaneous mast cells (MCs) express Mas-related G protein–coupled receptor-X2
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …

Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …

Mast cells (MCs) act as primary effectors in inflammatory and allergic reactions by releasing
intracellularly-stored inflammatory mediators in diseases. The two major pathways for MC …

MAS-related G protein-coupled receptors (GPCRs) of subfamily X, designated MRGPRX,
are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A …

The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms
independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by …

Mast cells are tissue-resident immune cells that play key roles in the initiation and
perpetuation of allergic inflammation, usually through IgE-mediated mechanisms. Mast cells …

Mast cells are phenotypically and functionally heterogeneous, and their state is possibly
controlled by local microenvironment. Therefore, specific analyses are needed to …

Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of
the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in …

Mast cells (MCs) are tissue resident immune cells that play important roles in the
pathogenesis of allergic disorders. These responses are mediated via the cross-linking of …

The G protein-coupled receptor MrgprX2 in mast cells is known to be a crucial receptor for
pseudo-allergic reactions. MrgprX2 activation leads to elevated intracellular calcium levels …