The Th2 cytokines interleukin 4 (IL‐4) and IL‐13 and the heterodimeric IL‐4 receptor (IL‐4R)
complexes that they interact with play a key role in the pathogenesis of allergic disorders …

Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

The concept of an alternative pathway of macrophage activation has stimulated interest in its
definition, mechanism, and functional significance in homeostasis and disease. We assess …

Vascular inflammation is associated with and in large part driven by changes in the
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …

Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large
B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young …

Vascular endothelial growth factor (VEGF) is an essential regulator of normal and abnormal
blood vessel growth. A monoclonal antibody (mAb) that targets VEGF suppresses tumor …

Atherosclerosis is a chronic progressive inflammation course, which could induce life‐
threatening diseases such as stroke and myocardial infarction. Optimal medical treatments …

Monocytes/macrophages are innate immune cells that play a crucial role in the resolution of
inflammation. In the presence of the Th2 cytokines interleukin-4 (IL-4) and interleukin-13 (IL …

The complexity of multicellular organisms is dependent on systems enabling cells to
respond to specific stimuli. Cytokines and their receptors are one such system, whose …

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2, CD213A), a high-affinity membrane
receptor of the anti-inflammatory Th2 cytokine IL-13, is overexpressed in a variety of solid …