Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

N-acetyl cysteine (NAC), as a nutritional supplement, is a greatly applied antioxidant in vivo
and in vitro. NAC is a precursor of L-cysteine that results in glutathione elevation …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Dysregulation of the immuno-inflammatory response, as seen in sepsis, may culminate in
host cell and organ damage. Lipopolysaccharide from Gram-negative bacterial cell walls …

Reactive oxygen species and thiol antioxidants, including glutathione (GSH), regulate innate
immunity at various levels. This review outlines the redox-sensitive steps of the cellular …

The excessive production of reactive oxygen species (ROS), associated with inflammation,
leads to a condition of oxidative stress. Oxidative stress is a major contributing factor to the …

Anthocyanins are a group of naturally occuring phenolic compounds related to the coloring
of plants, flowers and fruits. These pigments are important as quality indicators, as …

Apoptotic loss of parenchymal cells may lead to organ dysfunctions in critically ill patients
with septic states. As an antioxidant, the protective effects of N-acetylcysteine (NAC) are …

Objective Expression of inflammatory mediators is controlled in part at the transcriptional
level via nuclear factor-κB. Inhibition of nuclear factor-κB activation may be beneficial in …

Carrageenan is a high molecular weight sulfated polygalactan used to improve the texture of
commercial food products. Its use increased markedly during the last half century, although …