As cell signaling research has advanced, it has become clearer that signal transduction has
complex spatiotemporal regulation that goes beyond foundational linear transduction …

cAMP, a key player in many physiological processes, was classically considered to originate
solely from the plasma membrane (PM). This view was recently challenged by observations …

The dynamic signal encoding paradigm suggests that information flows from the
extracellular environment into specific signaling patterns (encoding) that are then read by …

Multiple biological processes are driven by oscillatory gene expression at different time
scales. Pulsatile dynamics are thought to be widespread, and single-cell live imaging of …

Molecular communications rely on diffusive propagation to transport information, which is
attractive for a variety of nano-scale applications. Due to the long-tail channel response …

How cells reliably infer information about their environment is a fundamentally important
question. While sensing and signaling generally start with cell-surface receptors, the degree …

From the timing of amoeba development to the maintenance of stem cell pluripotency, many
biological signaling pathways exhibit the ability to differentiate between pulsatile and …

Highlights•Pulsatile inputs regulate a wide range of cellular processes.•Responses to
pulsatile regimes depend on network circuitry and kinetic parameters.•Mathematical models …

Molecular communication is attractive to the emerging nano-scale communication systems.
Traditionally, a detector recovers the information from only the concentration of single …

Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis.
Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation …