The use of particulate carriers holds great promise for the development of effective and
affordable recombinant vaccines. Rational development requires a detailed understanding …

The tumor microenvironment consists of a variable combination of tumor cells, stromal
fibroblasts, endothelial cells and infiltrating leukocytes, such as macrophages, T …

Objectives In the current study, we have evaluated the clinical and immunological responses
in patients with advanced pancreatic carcinoma who received dendritic cell (DC)–based …

Flagellin, the structural protein subunit of the bacterial flagellum, is specifically recognized
by TLR-5 and has potent immunomodulatory effects. The antitumor effects of purified …

Background: This study addressed the potential of bacteriolytic therapy using Streptococcus
pyogenes in a syngeneic pancreatic carcinoma mouse model. Methods: Panc02 tumours …

It has previously been reported by our group that Toll-like receptor (TLR) 4 is involved in
anticancer immunity induced by OK-432, a Streptococcus-derived immunotherapeutic agent …

Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly
expand the in vivo research possibilities, and play a critical role in the development of …

We tested a new therapeutic modality for head and neck and esophageal cancers, a
combination of direct intratumoral (it) administration of dendritic cells (DCs) and radiation …

Signaling mediating colorectal cancer (CRC) progression is incompletely understood.
Previously, we identified lipopolysaccharide (LPS), an endotoxin of ubiquitously existing …

Abstract “Vaccell” is a dendritic cell (DC)-based cancer vaccine which has been established
in Japan. The DCs play central roles in deciding the direction of host immune reactions as …