Graphene and its chemical derivatives have been a pivotal new class of nanomaterials and
a model system for quantum behavior. The material's excellent electrical conductivity …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that
contributes to the epigenetic silencing of target genes and regulates the survival and …

Damage to the central nervous system (CNS) from degenerative diseases or traumatic
injuries is particularly devastating due the limited regenerative capabilities of the CNS …

CD133+ populations of human glioblastoma multiforme (GBM) cells are reportedly enriched
for tumor stem cells (TSCs) or tumor-initiating cells (TICs). Approximately 40% of freshly …

Both microRNAs (miRNAs) and epigenetic regulation have important functions in stem cell
biology, although the interactions between these two pathways are not well understood …

Recent molecular classification of glioblastoma (GBM) has shown that patients with a
mesenchymal (MES) gene expression signature exhibit poor overall survival and treatment …

The temporally and spatially restricted nature of the differentiation capacity of cells in the
neural lineage has been studied extensively in recent years. Epigenetic control of …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Lung cancer is the leading cause of cancer deaths, with small cell lung cancer (SCLC)
representing the most aggressive subtype. Standard treatments have not changed in …