Alzheimer's disease (AD) is incurable dementia closely associated with aging. Most cases of
AD are sporadic, and very few are inherited; the pathogenesis of sporadic AD is complex …

All living organisms depend on tightly regulated cellular networks to control biological
functions. Proteolysis is an important irreversible post-translational modification that …

Sjogren's syndrome (SS) is characterized by dysfunctional mucous membranes and
dysregulated moisture-secreting glands resulting in various symptoms, including dry mouth …

PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

Mature frataxin is essential for the assembly of iron–sulfur cluster proteins including a
number of mitochondrial enzymes. Reduced levels of mature frataxin (81-20) in human …

Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its
mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically …

Matrix metalloproteinases (MMPs) modify bioactive factors via selective processing or
degradation resulting in tumour-promoting or tumour-suppressive effects, such as those by …

Aberrant levels of the asparaginyl endopeptidase legumain have been linked to
inflammation, neurodegeneration, and cancer, yet our understanding of this protease is …

The mechanism whereby Entamoeba histolytica (Eh) binding with macrophages at the
intercellular junction triggers aggressive pro-inflammatory responses in disease …

The N-terminomics approach of Terminal Amine Isotopic Labeling of Substrates (TAILS)
enables the identification and quantification of natural and neo-N-termini of proteins using …