Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor,
and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is …

Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also
regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic …

Platelets are anucleated cells produced by megakaryocytes, from which they inherit all the
components necessary to carry their functions. They circulate in blood vessels where they …

Significance: The primary role of platelets is to generate a thrombus by platelet activation.
Platelet activation relies on calcium mobilization from the endoplasmic reticulum (ER). ER …

Background Obesity is accompanied by low-grade inflammation and leucocytosis and
increases the risk of venous thromboembolism. Associations with platelet count, however …

Lipid accumulation in hepatocytes is the distinctive characteristic of nonalcoholic fatty liver
disease. Serine/arginine-rich splicing factor 3 (SRSF3) is highly expressed in the liver and …

Abstract Background The small noncoding RNAs (sncRNAs) in megakaryocytes (MKs) and
platelets are not well characterized. Neither is the impact of SARS-CoV-2 infection on the …

Platelets are small circulating fragments of cells that play important roles in thrombosis,
haemostasis, immune response, inflammation and cancer growth. Although anucleate, they …

The serine/arginine-rich splicing factors (SRSFs) play an important role in regulating the
alternative splicing of precursor RNA (pre-RNA). During this procedure, introns are removed …

Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a
reduced platelet count as the main clinical manifestation, and often with abnormal platelet …