Comprehensive insight into exploring the potential of microbial enzymes in cancer therapy: Progress, challenges, and opportunities: A review

FS Hassan, EM El-Fakharany, YA El-Maradny… - International Journal of …, 2024 - Elsevier
Microbial enzymes are crucial catalysts in various industries due to their versatility and
efficiency. The microbial enzymes market has recently expanded due to increased demand …

Current advances in Candida tropicalis: Yeast overview and biotechnological applications

SS Queiroz, FM Jofre, IA Bianchini… - Biotechnology and …, 2023 - Wiley Online Library
Candida tropicalis is a nonconventional yeast with medical and industrial significance,
belonging to the CTG clade. Recent advancements in whole‐genome sequencing and …

Purification, Characterization and anticancer activity of L-methionine γ-lyase from thermo-tolerant Aspergillus fumigatus

MH Hendy, AH Hashem, WB Suleiman, MH Sultan… - Microbial cell …, 2023 - Springer
Purification of L-methionine γ-lyase (MGL) from A. fumigatus was sequentially conducted
using heat treatment and gel filtration, resulting in 3.04 of purification fold and 73.9% of …

Antibacterial and Anticancer Activity and Untargeted Secondary Metabolite Profiling of Crude Bacterial Endophyte Extracts from Crinum macowanii Baker Leaves

TE Sebola, NC Uche-Okereafor… - International Journal …, 2020 - Wiley Online Library
This study isolated and identified endophytic bacteria from the leaves of Crinum macowanii
and investigated the potential of the bacterial endophyte extracts as antibacterial and …

Bioprospecting of a Thermostable L-Methioninase from Alcaligenes aquatilis BJ-1 in Agro-Industrial Waste

B Javia, M Gadhvi, S Vyas, P Dudhagara… - Microbiology …, 2023 - mdpi.com
L-methioninase is an enzyme that has recently gained significant interest in the scientific
community because of its potential as a targeted therapy for cancer. This study aims to …

Process modeling and optimization of high yielding L-methioninase from a newly isolated Trichoderma harzianum using response surface methodology and artificial …

N Salim, A Santhiagu, K Joji - Biocatalysis and agricultural biotechnology, 2019 - Elsevier
A high yielding L-methioninase producing fungus was isolated from soil samples and was
identified as Trichoderma harzianum. The enzyme was purified using chromatographic …

An extensive review on L-methioninase and its potential applications

K Suganya, K Govindan, P Prabha… - Biocatalysis and …, 2017 - Elsevier
L-methioninase (METs) catalyses the disintegration of methionine, an essential amino acid
into ammonia, α-Keto glutarate and methanethiol. This enzyme has been extensively …

Enhanced l-Methioninase production by Methylobacterium sp. JUBTK33 through RSM and its anticancer potential

D Kavya, VK Nadumane - Biocatalysis and Agricultural Biotechnology, 2023 - Elsevier
Abstract l-Methioninase (EC 4.4. 1.11) has gained greater significance due to its anticancer
potential. In the present study, high l-Methioninase activity was seen in a newly isolated …

A review on L-methioninase in cancer therapy: Precision targeting, advancements and diverse applications for a promising future

BM Javia, MS Gadhvi, SJ Vyas, A Ghelani… - International Journal of …, 2024 - Elsevier
Cancer remains a global health challenge, demanding novel therapeutic options due to the
debilitating side effects of conventional treatments on healthy tissues. The review highlights …

Purification, characterization and anticancer evaluation of l-methioninase from Trichoderma harzianum

N Salim, A Santhiagu, K Joji - 3 Biotech, 2020 - Springer
The Trichoderma harzianum l-methioninase was purified 7.15-fold with a recovery of 47.9%
and the specific activity of 74.4 U/mg of protein. The purified enzyme has an apparent …