Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for developing next-generation analgesics. A prominent characteristic of …

Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …

Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …

We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is
not homogeneous, however, and comprises three categories: physiological, inflammatory …

The sensation of pain alerts us to real or impending injury and triggers appropriate
protective responses. Unfortunately, pain often outlives its usefulness as a warning system …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …