Advanced applications of RNA sequencing and challenges

Y Han, S Gao, K Muegge, W Zhang… - … and biology insights, 2015 - journals.sagepub.com
Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …

Epigenetics control microglia plasticity

M Cheray, B Joseph - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the
brain throughout life. These microglial functions range from participation in innate and …

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia

A Das, SH Kim, S Arifuzzaman, T Yoon, JC Chai… - Journal of …, 2016 - Springer
Background Microglia are resident myeloid cells in the CNS that are activated by infection,
neuronal injury, and inflammation. Established BV2 microglial cell lines have been the …

Plant–microbe interaction: aboveground to belowground, from the good to the bad

K Nadarajah, NSN Abdul Rahman - International Journal of Molecular …, 2021 - mdpi.com
Soil health and fertility issues are constantly addressed in the agricultural industry. Through
the continuous and prolonged use of chemical heavy agricultural systems, most agricultural …

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

A Hoffmann, B Ettle, A Bruno, A Kulinich… - Biochemical and …, 2016 - Elsevier
Synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB),
and multiple system atrophy (MSA) are defined by the presence of intracellular alpha …

Plant microbe interactions in post genomic era: perspectives and applications

J Imam, PK Singh, P Shukla - Frontiers in microbiology, 2016 - frontiersin.org
Deciphering plant–microbe interactions is a promising aspect to understand the benefits and
the pathogenic effect of microbes and crop improvement. The advancement in sequencing …

Milk derived extracellular vesicle uptake in human microglia regulates the DNA methylation machinery: Short title: milk-derived extracellular vesicles and the …

S Wijenayake, S Eisha, MK Purohit, PO McGowan - Scientific Reports, 2024 - nature.com
Mammalian milk contains milk-derived extracellular vesicles (MEVs), a group of biological
nanovesicles that transport macromolecules. Their ability to cross the blood brain barrier …

The BET inhibitor attenuates the inflammatory response and cell migration in human microglial HMC3 cell line

M Baek, E Yoo, HI Choi, GY An, JC Chai, YS Lee… - Scientific Reports, 2021 - nature.com
Microglia, resident macrophages of the brain that act as primary immune cells, play essential
roles in innate immunity and neuroinflammatory pathologies. Microglial cells are rapidly …

Identification of potential early diagnostic biomarkers of sepsis

Z Li, B Huang, W Yi, F Wang, S Wei, H Yan… - Journal of …, 2021 - Taylor & Francis
Objective: The goal of this article was to identify potential biomarkers for early diagnosis of
sepsis in order to improve their survival. Methods: We analyzed differential gene expression …

In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface

S Lee, HI Yoon, JH Na, S Jeon, S Lim, H Koo, SS Han… - Biomaterials, 2017 - Elsevier
It is urgently necessary to develop reliable non-invasive stem cell imaging technology for
tracking the in vivo fate of transplanted stem cells in living subjects. Herein, we developed a …