The tumor suppressor p53 plays a central role in the DNA damage response. After exposure
to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 …

The p53 tumor suppressor protein acts as a major defense against cancer. Among its most
distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this …

During the G1/S transition, p21 proteolysis is mediated by Skp2; however, p21
reaccumulates in G2 and is degraded again in prometaphase. How p21 degradation is …

Depending on multiple factors DNA damage leads either to cell cycle arrest or apoptosis.
One of the main players deciding the fate of a cell is the tumor suppressor p53 that …

A critical unresolved issue about the genotoxic stress response is how the resulting
activation of the p53 tumor suppressor can lead either to cell-cycle arrest and DNA repair or …

Post-translational modifications (PTMs) dynamically regulate the critical stress response and
tumor suppressive functions of p53. Among these, acetylation events mediated by multiple …

The cell cycle has the capacity to safeguard the cell's DNA from damage. Thus, cell cycle
arrest can allow tumor cells to investigate their own DNA repair processes. Cancer cells …

The aging liver is affected by several disorders, including steatosis, that can lead to a
decline of liver functions. Here, we present evidence that the cdk4-C/EBPα-p300 axis is a …

It has been reported that the induction of cellular senescence through p53 activation is an
effective strategy in tumor regression. Unfortunately, however, tumors including adult T-cell …

Hepatocellular carcinoma (HCC) has a high mortality rate worldwide, and there are still
many problems in the early diagnosis, molecular targeted therapy, and immunotherapy. It is …