Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review
examines how this diagnosis should be established and how to recognize …

The story began on 11th May 1857 when Charles Locock commented in the Lancet on his
use of potassium bromide in 15 cases of “hysterical” epilepsy in young women. The next …

We report 2 patients with drug‐resistant epilepsy caused by KCNT1 mutations who were
treated with quinidine. Both mutations manifested gain of function in vitro, showing …

Epilepsy, affecting about 1% of the population, comprises a group of disorders of the brain
characterized by the periodic and unpredictable occurrence of seizures. Epilepsy is a major …

Astrocytes are endowed with the machinery to sense and respond to neuronal activity.
Recent work has demonstrated that astrocytes play important physiological roles in the CNS …

Focal cortical dysplasias (FCDs) are malformations of cortical development (MCDs) that are
highly associated with medication-resistant epilepsy and are the most common cause of …

Background Malaria chemoprophylaxis prevents the occurrence of the symptoms of malaria.
Travellers to high-risk Plasmodium falciparum endemic areas need an effective …

Astrocytes sense and respond to synaptic activity through activation of different
neurotransmitter receptors and transporters. Astrocytes are also coupled by gap junctions …

Background: Gap junctions are clusters of intercellular channels allowing the bidirectional
pass of ions directly into the cytoplasm of adjacent cells. Electrical coupling mediated by gap …