Multiple sclerosis (MS) is a relatively common and etiologically unknown disease with no
cure treatment. It is the leading cause of neurological disability in young adults, affecting …

An explosion of new information about mitochondria reveals that their importance extends
well beyond their time-honored function as the “powerhouse of the cell.” In this Perspectives …

Objective: Our objective was to execute a prospective cohort study to determine
relationships between plasma mtDNA DAMP levels and the occurrence of systemic …

The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis
require further study of the factors underlying the progression of this disease. The prominent …

Mitochondrial dysfunction is associated with neuroinflammation and neurodegenerative
disease, but its role as a driver in these processes is uncertain. Understanding the …

The human DNA glycosylase NEIL1 was recently demonstrated to initiate prereplicative
base excision repair (BER) of oxidized bases in the replicating genome, thus preventing …

To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8)
modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living …

Although studies in rat cultured pulmonary artery endothelial cells, perfused lungs, and
intact mice support the concept that oxidative mitochondrial (mt) DNA damage triggers acute …

In cultured pulmonary artery endothelial cells and other cell types, overexpression of mt-
targeted DNA repair enzymes protects against oxidant-induced mitochondrial DNA (mtDNA) …

This study tested the hypothesis that oxidative mitochondrial-targeted DNA (mtDNA)
damage triggered ventilator-induced lung injury (VILI). Control mice and mice infused with a …